Oin 1992 scientists discovered a chemical in Gila monster venom which looked like GLP-1, activated GLP-1 receptors, but lasted a whole two hours. This became exenatide, the first GLP-1 receptor agonist (one of my favorite paper names is Exenatide: From The Gila Monster To The Pharmacy). By playing around with its structure, Big Pharma was eventually able to create liraglutide (twelve hours), semaglutide (one week), and cafraglutide (one month)
